• Fibrillar adhesion dynamics govern the timescales of nuclear mechano-response via the vimentin cytoskeleton

Beedle, AEM^†., Jaganathan, A., Albajar-Sigales, A., Yavitt, F.M., Bera, K., Andreu, I., Granero-Moya, I., Zalvidea, D., Kechagia, Z., Wiche, G., Trepat, X., Ivaska, J., Anseth, K.S., Shenoy, V., Roca-Cusachs, P^†.

Biorxiv: https://doi.org/10.1101/2023.11.08.566191

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• Force-Triggered Thermodynamically Uphill Disulfide Reduction through Sulfur Oxidation State Control

Mora, M., Cohen, C., Cranton, W., Anton, O., Beedle, AEM., Stirnemann, G., Garica-Manyes, S.

Journal of the American Chemical Society 147, 41, 37701-37707(2025)

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• Equibiaxial Stretching Device for High Magnification Live-Cell Confocal Fluorescence Microscopy

LeRoux, AL., Venturini, V., Gomez-Gonzalez, M., Beedle, AEM., Quiroga, X., Menino X., Trepat, X., Roca-Cusachs, P.

Journal of Visualized Experiments 220 e67520 (2025)

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• The reversibility of mechanotransduction

Beedle, AEM^†., Roca-Cusachs, P^†.

Current Opinion in Cell Biology 84, 102229 (2023)

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• The laminin-keratin link shields the nucleus from mechanical deformation and signalling

Kechagia, Z., Sáez, P., Gómez-González, M., Zamarbide, M., Andreu, I., Koorman, T., Beedle, AEM., Derksen, PWB., Trepat, X., Arroyo, M., Roca-Cusachs, P.

Nature Materials 22, 1409-1420 (2023)

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• The role of single protein elasticity in mechanobiology

Beedle, AEM., Garcia-Manyes, S.

Nature Reviews Materials 8, 1-24. (2023)

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• Moving towards a softer environment

Beedle, AEM., Roca-Cusachs, P.

Nature Materials (News and Views) 21, 995-996. (2022)

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• Mechanical force application to the nucleus regulates nucleoplasmic transport

Andreu, I*., Granero-Moya, I*., Chahare, N., Clein, K., Molina-Jordan, M., Beedle, AEM., Elosegui-Artola, A., Abenza, JF., Rossetti, L., Trepat, X., Raveh, B., Roca-Cusachs, P.

Nature Cell Biology 24, 896-905. (2022)            

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• The force loading rate drives cell mechanosensing through both reinforcement and fluidization

Andreu, I*., Falcones, B*., Hurst, S., Chahare, N., Quiroga, X., Le Roux, A., Kechagia, J., Beedle, AEM., Elosegui-Artola, A., Trepat, X., Farre, R., Betz, T., Almendros, I., Roca-Cusachs, P.

Nature Communications 12:4229 (2021)

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• Molecular fluctutations as a ruler of force-induced protein conformations

Stannard, A*., Mora, M*., Beedle, AEM*., Castro-lopez, M., Board, S., Garcia-Manyes, S.

Nano Letters 21, 7 2953-2961 (2021)    

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• The mechanical stability of proteins regulates their translocation rate into the nucleus

Infante, E*., Stannard, A*., Board, S., Rico-Lastres, P., Rostkova, E., Beedle, AEM., Lezamiz, A., Jian Wang, Y., Gulaidi Breen, S., Panagaki, F., Sundar Rajan, V., Shanahan, C., Roca-Cusachs, P., Garcia-Manyes., S.

Nature Physics 9: (2019) 

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• Forcing the reversibility of a mechanochemical reaction

Beedle, AEM*., Mora, M*., Davis, CT., Snijders, AP., Strinemann, G., Garcia-Manyes, S.

Nature Communications 9:3155 (2018)

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• Steering chemical reactions with force

Garcia-Manyes, S., Beedle, AEM.

Nature Reviews Chemistry 1: 0083 (2017)

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• Force triggers YAP entry by mechanically regulating transport across nuclear pores

Elosegui-Artola, A., Andreu, I., Beedle, AEM., Lezamiz, A., Uroz, M., Kosmalska, A., Oria, R., Kechagia, J., Rico-Lastres, P., Le Roux, A., Shanahan, C., Trepat, X., Navajas, D., Garcia-Manyes, S., Roca-Cusachs, P.

Cell 171, 1-14 (2017)

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• Tailoring protein nanomechanics with chemical reactivity

Beedle, AEM., Mora, M., Lynman, S., Stirnemann, G., Garcia-Manyes., S.

Nature Communications 8:15658 (2017)

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• The nanomechanics of lipid multibilayer stacks exhibits complex dynamics

Relat-Goberna, J., Beedle, AEM., Garcia-Manyes, S.

Small 13, 1700147 (2017)

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• Binding of myomesin to obscurin-like-1 at the muscle M-band provides a strategy for isoform-specific mechanical protection.

Pernigo, S., Fukuzawa, A., Beedle, AEM., Holt, M., Round, A., Pandini, A., Garcia-Manyes, S., Gautel, M., Steiner, SA.

Structure 25, 1-14 (2017)

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• Protein S-sulfenylation is a fleeting molecular switch that regulates non-enzymatic oxidative folding.

Beedle, AEM., Lynham, S., Garcia-Manyes, S.

Nature Communications 7:12490 (2016)

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• Single molecule identification of a misfolded, domain-swapped conformation in the cataract-forming human γD-crystallin.

Garcia-Manyes, S., Giganti, D., Badilla., C., Lezamiz, A., Perales-Calvo, J., Beedle, AEM., Fernandez, J.

The Journal of Biological Chemistry. 291(8): 4226 – 4235 (2016)

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• Mechanobiology – chemical origin of membrane mechanical resistance and force-dependent signalling.

Beedle, AEM., Williams, A., Relat-Goberna, J., Garcia-Manyes, S.

Current Opinion in Chemical Biology 29, 87-93 (2015)

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• The mechanochemistry of copper reports on the directionality of unfolding in model cupredoxin proteins.

Beedle, AEM., Lezamiz, A., Stirnemann, G., Garcia-Manyes, S.

Nature Communications 6:7894 (2015)